Splenomegaly And Hypersplenism
All are true of splenic abscess except A. Monomicrobial origin in more than 50% of...
Mitral facies
Mitral facies – distinctive facial appearance associated with mitral stenosis. Mitral facies -Pathology Mitral facies-...
Walthard cell nests
Walthard cell nests also called as Benign cluster of epithelial cells Most commonly found Most...
Image Question-43
What is the diagnosis of the Image? Scientific Figure on Research Gate. A. Sunflower Cataract...
Oil Droplet Cataract
Oil Droplet Cataract is seen commonly in A. Diabetes Mellitus B. Alpha-1 antitrypsin deficiency C....
Image Question-42
What is the diagnosis? What is the diagnosis of Image? A. Epidemic keratoconjunctivitis B. Vernal...
Cormack-Lehane classification system
Model for describing views in intubation CORMACK – LEHANE GRADING SYSTEM Grade 1: full view...
Image Question-41
Where is the most probable site of the lesion if the following visual field defect...
Meyer’s loop
Meyer’s loop is associated with A. Auditory Pathway B. Visual Pathway C. Basal ganglia Pathway...
Mortality in ankylosing spondylitis
Increased mortality in ankylosing spondylitis Increased mortality in ankylosing spondylitis is related to disease severity,...
Review Points
What is most common cause of chronic liver disease?Alcoholic Liver Disease What is most common…
Technique used in Molecular Biology
1Northern blotStudy gene expression by detection of RNA2Western blotused to detect specific proteins3Eastern blotanalyze protein…
Banding Techniques
Staining/banding. What is Banding Technique? Chromosome banding is an essential technique used in chromosome karyotyping…
Klinefelter syndrome
ALL of the following are clinical features of Klinefelter syndrome EXCEPT -A. weaker musclesB. short…
Hypoxic Cell Injury
What is the most common cause of cell injury?Hypoxia.Hypoxia is the most common cause of…
Motility Disorders – MCQs
Esophagus develops from the cranial portion of the foregut and is recognizable by -A. Second…
Chromosomal disorders -MCQs
Usual procedure to examine chromosomes is to arrest dividing cells in ———— ?A. ProphaseB. MetaphaseC….
Metaplasia – MCQs
Most common epithelial metaplasia is -A. Columnar to SquamousB. Squamous to Columnar C. Transitional to…
Edema – MCQs
Which of the following is characteristic finding in severe renal disease?A. Pedal edemaB. Sacral edemaC….
Vascular Function MCQs
Which of the following is CORRECT for a blood vessel as the vessels become smallerA….
Babesia
Maltese-cross form is a characteristic feature of which of the following parasite?A. Schistosoma mansoniB. Brugia malayiC….
Blast crisis
Blast crisis 1. Blast Crisis is Diagnoses when Blast count is -A. >10%B. > 20%C….
CRAB criteria
CRAB criteria is used for – A. Chronic Myeloid Leukemia B. Multiple Myeloma C.Renal Cell…
Medicine MCQs – 23
Which medicine dramatically alters the natural course of PNH, reducing symptoms and disease complications as well as improve survival?
Eculizumab- is a medication used to treat
- paroxysmal nocturnal hemoglobinuria (PNH)
- atypical hemolytic uremic syndrome (aHUS)
- generalized myasthenia gravis
- neuromyelitis optica
All of the following are correct about Eculizumab EXCEPT -
Meningococcal vaccination is recommended at least 2 weeks before receiving eculizumab
Which of the following support a diagnosis of hemolysis?
Decrease in haptoglobin and Low Hb and Hematocrit support a diagnosis of hemolysis
Which is the most common site for thrombosis in PNH patients?
Hepatic vein thrombosis (Budd-Chiari syndrome) is recognized as one of the most common sites of thrombosis
Hepatic failure is a common cause of mortality in PNH
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein -
Eculizumab is a recombinant humanized monoclonal antibody against the complement protein C5
Under normal circumstances, free hemoglobin released by hemolysis is removed by -
Clinical settings - Haptoglobin assay is used to screen for and monitor intravascular hemolytic anemia.
In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels.
All of the following are CORRECT about thrombosis in PNH patients EXCEPT -
Cerebral venous thrombosis is common
Cerebral venous system is the second most frequent location of thrombosis after hepatic veins.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602837/
All of the following are useful in treatment of Paroxysmal nocturnal hemoglobinuria as required EXCEPT:
Long-term glucocorticoids not useful and contraindicated
All of the following are correct for Paroxysmal nocturnal hemoglobinuria EXCEPT:
In PNH - Mutation of the X-linked gene phosphatidylinositol glycan class A (PIGA), produces a deficiency in the glycosylphosphatidylinositol (GPI) protein, which is responsible for anchoring other protein moieties to the surface of erythrocytes.
Most common finding in Paroxysmal nocturnal hemoglobinuria is -
Paroxysmal nocturnal hemoglobinuria (PNH) - most common- hemolytic anemia, hemoglobinuria, and shortness of breath.
Other findings - thrombosis, renal insufficiency, and bone marrow failure.
Ankle:Brachial Index
What is Ankle Brachial Index? ABI is a non-invasive tool for the assessment of vascular…
