A. weaker muscles
B. short height
C. poor motor coordination
D. less body hair
Symptoms of Klinefelter syndrome –
– weaker muscles
– greater height
– poor motor coordination
– less body hair
– breast growth
– less interest in sex.
A. male hypogonadism
B. female hypogonadism
C. male hermaphrodite
D. female hermaphrodite
Klinefelter syndrome is best defined as male hypogonadism
A. 47, XY
B. 45, XXY
C. 47, XXY
D. 45, XY
Klinefelter Syndrome – 47, XXY
1. Karyotypes are usually prepared from blood.
2. The red blood cells (which lack a nucleus and hence, chromosomes) are allowed to settle out and then the white blood cells (which do possess a nucleus) are treated with colchicine.
3. Colchicine stops mitosis at metaphase (by preventing the formation of microtubules) when chromosomes are spread out for the easiest viewing.
4. The treated cells are fixed, stained and examined microscopically.
A. type 2 diabetes
B. metabolic syndrome
C. mitral valve prolapse
D. mental retardation
– mental retardation is uncommon.
There is increased incidence of –
– type 2 diabetes
– metabolic syndrome
– insulin resistance.
– mitral valve prolapse is seen in about 50% of adults with Klinefelter syndrome.
– increased incidence of osteoporosis
A. Inherited condition
B. Maternal age is the only known risk factor
C. Low serum testosterone level
D. High serum follicle-stimulating hormone
Klinefelter syndrome is not an inherited condition.
Maternal age is the only known risk factor.
Standard diagnostic method is the analysis of the chromosomes’ karyotype on lymphocytes
Standard postnatal diagnostic testing –
– Karyotype analysis on peripheral blood lymphocytes,
– XCAT-KS buccal swab test,
– fluorescence in-situ hybridization (FISH),
– microarrays are options for postnatal diagnostic testing.