Heart Failure Cells

“Heart failure” cells

“Heart failure” cells seen commonly in

[A] Lungs
[B] Heart
[C] Spleen
[D] Liver

“Heart failure” cells

Heart failure cells – are siderophages generated in the alveoli of the lungs of people with left heart failure or chronic pulmonary edema

“Heart failure” cells


  • Heart Failure causes Pulmonary congestion
  • High pulmonary pressure
  • Blood cells pass through vascular wall
  • Degradation of hemoglobin yields iron
  • which is stored in hemosiderin granules
  • Hemosiderin-laden macrophages are traditionally named HF cells or siderophages
  • Pulmonary hemosiderin-laden macrophages are formed when ferritin is oxidized by phagocytosed red blood cells (RBC) within alveolar macrophages.
  • Any condition leading to increased RBC within the alveolar space can result in hemosiderin-laden macrophages

siderophage is a hemosiderin-containing macrophage

Heart failure cells are siderophages generated in the alveoli of the lungs of people with left heart failure or chronic pulmonary edema, when the high pulmonary blood pressure causes red blood cells to pass through the vascular wall.

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