Contents
- 1 Mature GBM consists of
- 2 Major symptom of ‘Thin Basement Membrane Disease’
- 3 Type IV collagen is the antigenic target in
- 4 ALL are TRUE about Alport syndrome EXCEPT
- 5 Commonest type of hearing loss in Alport syndrome?
- 6 Occular finding characteristic feature of Alport syndrome
- 7 Which is the commonest ocular manifestation of Alport syndrome in males with XLAS.
- 8 In-shorts
- 9 Alport syndrome
- 10 Sensorineural hearing loss
- 11 Hematuria
- 12 Proteinuria
- 13 Anterior lenticonus
- 14 Dot-and-fleck retinopathy
- 15 Diffuse leiomyomatosis
Mature GBM consists of
A. Type I collagen
B. Type II collagen
C. Type III collagen
D. Type IV collagen
Major symptom of ‘Thin Basement Membrane Disease’
A. Hematuria
B. Hypercalciuria
C. Proteinuria
D. Hyperuricosuria
Type IV collagen is the antigenic target in
A. Cystinosis
B. Alport syndrome
C. Goodpasture disease
D. Fabry disease
ALL are TRUE about Alport syndrome EXCEPT
A. Loss of hearing and eye abnormalities
B. Abnormality of a gene that codes for type IV collagen
C. 80% of cases Alport syndrome is inherited as autosomal recessive pattern
D. Gross or microscopic hematuria is the commonest and earliest sign of Alport syndrome
Commonest type of hearing loss in Alport syndrome?
A. Conductive Hearing Loss
B. Sensorineural Hearing Loss
C. Mixed Hearing Loss
D. Auditory Neuropathy Spectrum Disorder
Occular finding characteristic feature of Alport syndrome
A. Posterior polymorphous corneal dystrophy
B. Severe temporal macular thinning
C. Anterior lenticonus
D. Giant macular holes
Which is the commonest ocular manifestation of Alport syndrome in males with XLAS.
A. Purtscher’s retinopathy
B. Dot-and-fleck retinopathy
C. Valsalva retinopathy
D. Macular Photocoagulation
In-shorts
Alport syndrome
Sensorineural hearing loss
Sensorineural hearing loss is a characteristic feature observed commonly, but not universally, in Alport syndrome.
Hearing loss is never congenital.
Bilateral, high-frequency sensorineural deafness usually begins in late childhood or early adolescence, before the onset of kidney failure.
Hematuria
Gross or microscopic hematuria is the commonest and earliest sign of Alport syndrome.
Proteinuria
Proteinuria is generally absent in childhood but ultimately develops in males with XLAS and male and female patients with ARAS
Sensorineural hearing loss is a characteristic feature observed commonly, but not universally, in Alport syndrome. Hearing loss is never congenital.
Anterior lenticonus
Anterior lenticonus, occurring in around 25% of patients with XLAS, is a characteristic feature of Alport syndrome.
Dot-and-fleck retinopathy
Dot-and-fleck retinopathy is the commonest ocular manifestation of Alport syndrome, occurring in around 85% of males with XLAS.
Diffuse leiomyomatosis
Diffuse leiomyomatosis of the tracheobronchial tree and esophagus has been observed in some families with Alport syndrome
