Collier’s sign

Collier’s sign also known as –

A. Dalrymple sign

B. Posterior fossa stare

C. von Graefe’s sign

D. Vertical Gaze Palsy

Collier’s sign is a medical sign of

A. Frontal lobe lesion

B. Pontine Lesion

C. Midbrain lesion

D. Cerebellar Lesion

All of the following are seen in signs of Parinaud syndrome EXCEPT –

A. setting sun sign

B. posterior fossa stare

C. Paralysis of vertical gaze

D. vestibulo-ocular reflex absent

All of the following are classical triad of Parinaud syndrome EXCEPT –

A. Oscillopsia

B. Upgaze palsy

C. Convergence retraction nystagmus

D. Pupillary hyporeflexia

Collier’s sign

  • Eyes in the primary position- sclera can be seen above the cornea.
  • Upgaze increases the distance between the eyelids and irises.

Collier’s sign -Mechanism :

Damage to the posterior commissure levator inhibitory fibres.

Lid retraction in the primary position, which is called the Collier sign.

Mechanism of Collier’s sign – damage to the levator inhibitory fibers at the posterior commissure.

Posterior commissure levator inhibitory fibres – originate in the M-group of neurons

Causes of Collier’s sign include upper dorsal midbrain supranuclear lesions such as –

  1. Parinaud’s syndrome,
  2. ‘Top of the basilar syndrome’,
  3. Midbrain infarction,
  4. Neurodegeneration or tumour,
  5. Multiple sclerosis,
  6. Encephalitis,
  7. Miller-Fisher syndrome

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