Podocytes are highly specialized cells of the

A. Kidney

B. Liver

C. Spleen

D. Intestinal brush border

Podocytes are cells in

A. Ascending limb

B. Descending limb

C. Glomerulus

D. Collecting Duct

Which cells become podocytes?

A. Myoepithelial cells

B. Parietal epithelial cells

C. Visceral epithelial cells

D. Mesangial cells

Which is a zipper-like protein that forms the slit diaphragm, big enough to allow sugar and water through but too small to allow proteins through?

A. Uromodulin

B. Nephrin

C. Urochrome

D. Apolipoprotein A

Major cause of podocyte injury in Adriamycin Toxicity?

A. Anti-GBM antibodies

B. Actin reorganization

C. Podocyte polarity charge distortion

D. Mitochondrial dysfunction

Foot process disease is other name of

A. Minimal change disease

B. Focal glomerulosclerosis

C. IgA nephropathy

D. Membranous nephropathy

Finnish-type nephrosis, which is characterised by neonatal proteinuria is found to be caused by a mutation in the



C. laminin-β2

D. WT1

Wilms’ tumor suppressor gene mutations lead to all EXCEPT

A. Denys-Drash syndrome

B. Frasier syndrome

C. WAGR syndrome

D. Congenital nephrotic syndrome Finnish type

Visceral epithelial cells

On invasion by blood vessels, parietal and visceral epithelial cells build up the renal corpuscle.

  1. Visceral epithelial cells – become podocytes
  2. Parietal epithelial cells – form the parietal layer of Bowman’s capsule.

Podocytes make up the epithelial lining of Bowman’s capsule

Nephrin – is a zipper-like protein that forms the slit diaphragm, with spaces between the teeth of the zipper big enough to allow sugar and water through but too small to allow proteins through.

Mechanism of Ultrafiltration

Podocytes are found lining the Bowman’s capsules in the nephrons of the kidney.

The foot processes known as pedicels that extend from the podocytes wrap themselves around the capillaries of the glomerulus to form the filtration slits.

The pedicels increase the surface area of the cells enabling efficient ultrafiltration.

The slits are covered by slit diaphragms which are composed of a number of cell-surface proteins including nephrin, podocalyxin, and P-cadherin, which restrict the passage of large macromolecules such as serum albumin and gamma globulin and ensure that they remain in the bloodstream.

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