Alcoholic Liver Disease
Primary Sclerosing Cholangitis is the most common hepatobiliary manifestation seen in IBD.
IBD is present in 70–80% of Primary Sclerosing Cholangitis patients.
In patients with Primary Sclerosing Cholangitis and IBD, 85–90% have ulcerative colitis
The stellate cells are thought to be the source of collagen in pathological conditions.
Chronic liver injury activates hepatic stellate cells, which are activated and transformed into a myofibroblast-like phenotype.
They then lay down the extracellular matrix.
Ochronosis- Most commonly affected tissues are the cartilages
Chronic malaria and in Mismatched blood transfusions
Porphyria cutanea tarda is the most common of all porphyrias.
Argyria is chronic ingestion of silver compounds.
Argyria results in brownish pigmentation in the skin, bowel, and kidney.
COAGULATIVE NECROSIS- is the most common type of necrosis caused by ischaemia.
– Uterine cervix
– Bronchial mucosa
Temperature above 40 degrees C (104 degrees F) in the presence of any of the following symptoms
Hot, red, dry skin
Tachycardia with a strong pulse
Delirium, convulsions, or coma