Contents
- 1 How the ‘Howell-Jolly bodies’ is produced?
- 2 What is the clinical significance of presence of ‘Howell-Jolly bodies’ in peripheral smear?
- 3 Most common cause of ‘Howell-Jolly bodies?
- 4 What are the causes of ‘Howell-Jolly bodies’?
- 5 Howell-Jolly bodies
- 6 Target cells (codocytes)
- 7 Bullseyes appearance of Cells
- 8 Spherocytes
- 9 Spherocytes, noted by the lack of a pale center can been seen most commonly in
- 10 Schistocytes & helmet cells
- 11 Schistocytes (red arrow) and helmet cells (blue arrow) are common in –
What is the diagnosis of the Image?
A. Pappenheimer bodies
B. Howell-Jolly bodies
C. Schaumann body
D. Ateroid body
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Paulo Henrique Orlandi Mourao and Mikael Häggström, CC BY-SA 3.0 , via Wikimedia Commons
How the ‘Howell-Jolly bodies’ is produced?
In the bone marrow, late erythroblasts normally expel their nuclei; but, in some cases, a small portion of DNA remains which appears as Howell-Jolly bodies.
What is the clinical significance of presence of ‘Howell-Jolly bodies’ in peripheral smear?
Normally a healthy spleen removes red blood cells with ‘Howell-Jolly bodies’.
Presence of ‘Howell-Jolly bodies’ in peripheral smear suggests damaged or absent spleen,
Most common cause of ‘Howell-Jolly bodies?
‘Howell-Jolly bodies’ – Most commonly present in patients with absent or impaired function of the spleen
What are the causes of ‘Howell-Jolly bodies’?
Howell-Jolly bodies – pathognomonic for splenic dysfunction, but can be found in other disorders:
- post-splenectomy,
- sepsis,
- congenital disorders,
- sickle cell hemoglobinopathies,
- alcoholism,
- lupus and other autoimmune disorders,
- post-bone marrow transplantation.
Howell-Jolly bodies
Target cells (codocytes)
Target cells (codocytes)
Bullseyes appearance of Cells
Target cells (codocytes) appear as bullseyes, seen in
1. liver disease,
2. alpha/beta thalassemia,
3. hemoglobin C disease
4. asplenia
Target cells (codocytes) appear as bullseyes, seen in
1. liver disease,
2. alpha/beta thalassemia,
3. hemoglobin C disease
4. asplenia
Bullseyes appearance of Cells
Target cells (codocytes) appear as bullseyes, seen in
- liver disease,
- alpha/beta thalassemia,
- hemoglobin C disease
- asplenia
Spherocytes
Spherocytes
Spherocytes, noted by the lack of a pale center can been seen most commonly in
– hemolytic anemia
– hereditary spherocytosis)
– hemolytic anemia
– hereditary spherocytosis)
Spherocytes, noted by the lack of a pale center can been seen most commonly in
- hemolytic anemia
- hereditary spherocytosis)
Schistocytes & helmet cells
Schistocytes & helmet cells
Schistocytes (red arrow) and helmet cells (blue arrow) are common in –
Mechanism – shearing or mechanical destruction of the red cells. –
Diseases –
1. disseminated intravascular coagulation
2. thrombotic thrombocytopenic purpura
3, aortic stenosis.
Mechanism – shearing or mechanical destruction of the red cells. –
Diseases –
1. disseminated intravascular coagulation
2. thrombotic thrombocytopenic purpura
3, aortic stenosis.
Schistocytes (red arrow) and helmet cells (blue arrow) are common in –
Mechanism – shearing or mechanical destruction of the red cells. –
Diseases –
- disseminated intravascular coagulation
- thrombotic thrombocytopenic purpura
3, aortic stenosis.
