Alder–Reilly anomaly

Alder-Reilly bodies –

• Alder-Reilly anomaly is seen in – mucopolysaccharidoses.
• Most characteristic finding – metachromatic granules surrounded by a clear zone seen in lymphocytes.
• Dense granules [like toxic granulation in neutrophils] – seen in all leukocytes.
• Granulocytes show metachromatic and darkly staining inclusions containing partially digested mucopolysaccharides
• Inherited abnormality of white blood cells associated with mucopolysaccharidosis
• Alder–Reilly inclusions – appear violet when treated with Wright–Giemsa stain
• Affected white blood cells function normally
• Granules Shape – round or comma-shaped
• Granules surrounded by a clearing in the cytoplasm – granules appear to be within small vacuoles.

Alder-Reilly bodies

Most characteristic finding is the metachromatic granules surrounded by a clear zone seen in lymphocytes.

NOTICE –
Cytoplasmic metachromatic granules, which appear to be within small vacuoles.

Author: Teaching collection Vicky Smith
https://imagebank.hematology.org/

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Figure 1: (a) Prominent dark staining and coarse cytoplasmic granules in polymorphonuclear neutrophil similar to toxic granules but larger and coarser. Wright–Giemsa stain 1000.

(b) A lymphocyte from the same patient remarkable for the presence of many cytoplasmic metachromatic granules, which appea…