Ketone bodies


Ketone bodies are produced mainly in


A. Liver

B. Brain

C. Heart

D. Lipocytes



Ketone bodies enters the citric acid cycle in the form of –


A. α-Ketoglutarate

B. Malonyl-CoA 

C. Acetyl-CoA

D. Succinyl-CoA



All of the following are Ketone bodies produced by the liver EXCEPT –


A. α-Ketoglutaric acid

B. acetoacetic acid

C. beta-hydroxybutyrate

D. acetone



Ketone bodies are usually produced in liver cells by the breakdown of –


A. Carbohydrates

B. Fatty acids

C. Alcohol

D. Proteins



Glycogen stores typically are depleted within the first ———— hours of fasting.


A. 12

B. 24

C. 48

D. 72



What is the characteristic smell of Ketone bodies in patients with ketosis?


A. Fruity

B. Musty

C. Urine

D. Fishy



Fatty acids can only be metabolized in


A. Endoplasmic reticulum

B. Mitochondria

C. Ribosome

D. Nucleolus


Red blood cells entirely dependent on ————– for their energy requirements.


A. Electron transport chain

B. Oxidative Phosphorylation

C. Anaerobic glycolysis

D. Kreb cycle



Ketone bodies can be used as fuel in ALLof the following EXCEPT-


A. Heart

B. Brain

C. Muscle

D. Liver



Liver cannot use ketone bodies for energy because it lacks the enzyme –


A. Fumarase

B. Aconitase

C. Thiophorase

D. Citrate synthase


Heart preferentially uses ——————- as fuel under normal physiologic conditions.

A. Amino acids

B. Glucose

C. Fatty acids

D. Ketone bodies



Which structure in the brain can locally synthesized ketone bodies in food restrictive conditions –


A. Neurons

B. Purkinje cells

C. Glial cells

D. Synapses



In-Shorts


Endogenous ketone bodies-


  • Acetoacetic acid
  • Beta-hydroxybutyrate
  • Acetone

Other ketone bodies –


β-ketopentanoate and β-hydroxypentanoate

may be created as a result of the metabolism of synthetic triglycerides, such as triheptanoin


Triheptanoin –


Medication for the treatment of children and adults with molecularly confirmed long-chain fatty acid oxidation disorders (LC-FAOD)


“sweet & fruity” odor in breath of persons in ketosis or ketoacidosis is due to –

Acetone


Breath Smells – fruity or like nail polish remover

Acetone produced by ketogenesis – patients can have breath that smells fruity or like nail polish remover


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