Alder-Reilly bodies –
- Alder-Reilly anomaly is seen in – mucopolysaccharidoses.
- Most characteristic finding – metachromatic granules surrounded by a clear zone seen in lymphocytes.
- Dense granules [like toxic granulation in neutrophils] – seen in all leukocytes.
- Granulocytes show metachromatic and darkly staining inclusions containing partially digested mucopolysaccharides
- Inherited abnormality of white blood cells associated with mucopolysaccharidosis
- Alder–Reilly inclusions – appear violet when treated with Wright–Giemsa stain
- Affected white blood cells function normally
- Granules Shape – round or comma-shaped
- Granules surrounded by a clearing in the cytoplasm – granules appear to be within small vacuoles.
Cytoplasmic metachromatic granules, which appear to be within small vacuoles.
Author: Teaching collection Vicky Smith
(b) A lymphocyte from the same patient remarkable for the presence of many cytoplasmic metachromatic granules, which appea…