Image Question-23

What is the diagnosis of Image?

Histology slide of the spleen showing Gamna-Gandy bodies and haemosiderin pigment

Bhatt S, Simon R, Dogra VS., CC BY 3.0, via Wikimedia Commons

What is the diagnosis of histopathological slide?

A. Fessas  body

B. Gamna-Gandy body

C. Lafora body

D. Mallory body

Gamna-Gandy bodies

Gamna-Gandy bodies
Other namesTobacco flecks or Siderotic nodules
Appearance Yellow-brownish and spheroidal foci within the splenic parenchyma
CompositionDeposits of iron pigments and calcium salts
Associated withGranulomatous inflammatory reactions with multinucleated foreign-body giant cells
Common ConditionsPortal hypertension , Sickle cell disease
Gamna-Gandy bodies

What are Fessas bodies?

Fessas bodies – intracellular inclusion bodies in peripheral blood smears of patients with thalassemias.

Neoplastic Diseases may have Gamna-Gandy bodies

  • Thymoma
  • Thyroid Follicular Adenoma
  • Pituitary Adenoma
  • CNS Neoplasms
  • Hairy Cell Leukemia
  • Hodgkin and non-Hodgkin Lymphoma
  • Cardiac Myxomas
  • Angiosarcoma
  • Ovary Carcinoma
  • Liver Carcinoma
  • Renal Cell Carcinoma
  • Breast Cancer
  • Gastric Neurinoma

Non-neoplastic Diseases

  • Portal Hypertension
  • Thrombotic Thrombocytopenic Purpura
    Idiopathic Thrombocytopenic Purpura
  • Hemolytic Anemia
  • Paroxysmal Nocturnal Hemoglobinuria
  • Acquired Hemochromatosis
  • Congestive Splenomegaly
  • Retroperitoneal Lymph Nodes

Splenic Gandy-Gamna body

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