Dutcher body

1. inclusion body structure seen in the nucleus
2. highly specific to neoplastic myeloma cells
3. Presence of Dutcher body indicates neoplastic characteristics
4. Dutcher bodies – invaginate into or overlie the nucleus (intranuclear pseudo inclusions)
5. Russell bodies – clearly seen to be within the cytoplasm.

Russel bodies – are sometimes found in reactive plasma cells,therefore, their presence is not definitive for neoplasticity