Cervical Intraepithelial Neoplasia

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High grade squamous intraepithelial lesion (HSIL) includes all except

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A. Basal one-third only
B. Whole thickness
C. Whole thickness except one or two superficial layers
D. Basal half to two-third

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LSIL, low grade squamous intraepithelial lesions includes

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A. Severe dysplasia
B. Koilocytic atypia
C. Carcinoma in situ
D. Dyskaryotic cells

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Carcinogenesis in cervix starts at the ‘transformation zone’ (TZ) by

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A. Squamous metaplasia of the sub columnar reserve cells
B. Reduction in number of lactobacilli
C. Squamous epidermidization
D. Host cell immortalization

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Risk factors in the genesis of cervical cancer are all except

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A. Infection with high-risk HPV
B. Multiple types of HPV
C. Persistence of infection
D. Post menopause

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HPV of high oncogenic risk is

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A. 6
B. 11
C. 33
D. 42

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True of HPV DNA is

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A. Over 57 percent of patients with CIN and invasive cancer are found to be positive with HPV DNA.
B. HPV DNA detection in cervical tissues may be a screening procedure as that of Pap smear.
C. HPV infected cells (koilocytes) contain dispersed chromatin in the cytoplasm
D. Expression of p55 oncoproteins in the infected cells

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Not true about koilocytes

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A. Large cells
B. Columnar cell
C. Vacuolated cells
D. Contain perinuclear halo

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In shorts

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• HPV Triage Strategy includes: Pap Smear test, HPV testing, Colposcopy

• Exfoliative cytology, the gold standard for screening, should contain cells from SCJ, TZ and the endocervix.

• Hybrid capture methods can reliably detect the high risk HPV types early.

• Colposcopy is complementary and not a substitute for cytology.

• Schiller’s test: Employing iodine solution (Schiller’s 0.3% or Lugol’s 5%), multiple punch biopsies can be taken from the unstained areas in absence of colposcopy.

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