Bombesin
Bombesin
Bombesin
All of the following are classified as Bombesin receptors EXCEPT
[A] VCAM-1[B] Gastrin-releasing peptide receptor
[C] Orphan receptor
[D] Neuromedin-B receptor
Bombesin receptors
Bombesin receptors are G-protein-coupled receptors.
These receptors classify into three different types.
- Neuromedin-B receptor – bombesin receptor 1
- Gastrin-releasing peptide receptor ([GRPR] also known as bombesin receptor 2 [BRS1, BB2, BBR-2]).
- Orphan receptor – known as bombesin receptor 3
Function
Function
Brain- bombesin is known as neuromedin B and is involved in smooth muscle contraction.
LUNGS- Bombesin is present in regions of the trachea, bronchus, and within the whole lung at different stages of human fetal development.
Neoplastic tissues- Bombesin function as a growth factor through autocrine or paracrine mechanisms, which may modulate the growth of various benign and neoplastic tissues
Bombesin is present in neonates, children, and adults