Blast crisis

Blast crisis


Blast crisis is the final phase in the evolution of CML,.

In this phase CML behaves like an acute leukemia,

  • rapid progression
  • short survival.
BLAST CRISIS – DIAGNOSISAny of the following present in CML
120% blasts in the blood or bone marrow
2Extramedullary proliferation of blasts
BLAST CRISIS
Imatinib Useful in Blast crisis of CML
inhibitor targeted at the BCR-ABL tyrosine kinase
BCR-ABL expression can be reduced by imatinib to very low or nondetectable levels
Median survival in chronic phase is estimated at a median of 25 to 30 years.
BC has been reduced to 1% to 1.5% per year
Imatinib in CML

Chronic myelogenous leukemia

Imatinib – inhibitor targeted at the BCR-ABL tyrosine kinase

Imatinib – has fundamentally changed treatment of CML.

BCR-ABL expression can be reduced by imatinib to very low or nondetectable levels in the majority of patients.

Median survival in chronic phase is estimated at a median of 25 to 30 years.

Progress to advanced phase CML or BC has been reduced to 1% to 1.5% per year

Blast Crisis Symptoms
1night sweats
2weight loss
3fever
4bone pain
5symptoms of anemia
Blast Crisis Symptoms

Blast crisis is associated with – additional cytogenetic aberrations (ACAs) in addition to the Philadelphia (Ph)–chromosome.

Blast crisis is associated with – additional cytogenetic aberrations with Philadelphia (Ph)–chromosome

Most frequent are the so called “major route” ACA
1Trisomy 8
2Additional Ph-chromosome
3Isochromosome (17q)
4Trisomy 19)
cytogenetic aberrations (ACAs) in addition to the Philadelphia (Ph)–chromosome

which are nonrandom and considered relevant for the pathogenesis of BC

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