Biotransformation


Biotransformation is a metabolic process that takes place mainly in the


A. Kidney

B. Liver

C.Adipose tissue

D. Skin



Biotransformation helps to facilitate the excretion of


A. Endogenous substances

B. Exogenous substances

C. Both exogenous and endogenous substances

D. Do not help in excretion



Phase I gives rise to a product for which all are TRUE EXCEPT


A. Non-polar

B. Water-soluble

C. Product is often still active

D. All are True



All of the following are biotransformation phase I reactions Except


A. Oxidation with cytochrome P450

B. Reduction

C. Hydrolysis

D. Acetylation



Which is most common biotransformation phase I reactions 


A. Oxidation with cytochrome P450

B. Reduction

C. Hydrolysis

D. Methylation



Which is most common biotransformation phase I reactions 


A. Methylation
B. Glucuronidation
C. Acetylation
D. Conjugation with glutathione



Drugs with CYP activity may be inhibitors all EXCEPT


A. Valproic Acid

B. Chronic use of Alcohol

C. Azole antifungals

D. Isoniazid




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