Organophosphorus


Organophosphorus inhibit ————— to cause clinical features of acute poisoning


A. Butyrylcholinesterase 

B. Acetylcholinesterase

C. Muscarinic receptors

D. Nicotinic receptors



All are features due to overstimulation of muscarinic acetylcholine receptors in the parasympathetic system Except


A. Urination

B. Bronchorrhoea

C. Mydriasis

D. Bronchospasm



All of the following are features due to overstimulation of nicotinic acetylcholine receptors in the sympathetic system EXCEPT


A. Tachycardia
B. Mydriasis
C. Hypotension
D. Sweating



All of the following are features due to overstimulation of nicotinic and muscarinic acetylcholine receptors in the CNS EXCEPT


A. Confusion
B. Agitation
C. Fasciculations
D. Respiratory failure



All of the following are features due to overstimulation of nicotinic acetylcholine receptors at the neuromuscular junction EXCEPT


A. Muscle weakness

B. Paralysis

C. Fasciculations

D. Coma



Intermediate syndrome is seen in


A. Atropin poisoning

B. Oxime Treatment

C. Head injury

D. Organophosphorus poisoning



Which measurement more accurately reflects nervous system Organophosphate  acetylcholinesterase inhibition


A. RBC Butyrylcholinesterase

B. RBC Acetylcholinesterase 

C. Pseudocholinesterase

D. Anticholinesterase



If excess atropine is given to a patient then we observe all of the following EXCEPT


A. agitation

B. pyrexia

C. absent bowel sounds

D. urinary incontinence



Recurring cholinergic crises in organophosphorus poisoning is due to


A. Inadequate atropine

B. Pralidoxime is not added in treatment plan

C. Reintake of organophosphorus

D. Release of fat soluble organophosphorus from fat stores



In shorts


Clinical features of organophosphorus poisoning


Overstimulation of acetylcholine receptorsFeatures
1 Muscarinic acetylcholine receptors in the parasympathetic systemBronchospasm
Bronchorrhoea
Miosis
Lachrymation
Urination
Diarrhoea
Hypotension
Bradycardia
Vomiting
Salivation
2Nicotinic acetylcholine receptors in the sympathetic systemTachycardia
Mydriasis
Hypertension
Sweating
3Nicotinic and muscarinic acetylcholine receptors in the CNSConfusion
Agitation
Coma
Respiratory failure
4Nicotinic acetylcholine receptors at the neuromuscular junctionMuscle weakness
Paralysis
Fasciculations
Organophosphorus poisoning

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