Substantia nigra

Substantia nigra is located in –

A. Midbrain

B. Hippocampus

C. Motor cortex

D. Thalamus


Substantia nigra appear darker than neighboring areas due to high levels of –

A. Hemosiderin

B. Lutein

C. Neuromelanin

D. Zeaxanthin


Parkinson’s disease is characterized by the loss of dopaminergic neurons in –

A. Pars reticulata

B. Pars compacta

C. Pars plicata

D. Pars nervosa


Projections from the Substantia nigra to the putamen, called –

A. Tuberoinfundibular pathway

B. Mesocortical pathway

C. Nigrostriatal pathway

D. Mesolimbic pathway

Nigrostriatal pathway is critically involved in the motor deficits observed in –

A. Parkinson disease

B. Amyotrophic lateral sclerosis

C. Alzheimer’s disease

D. Multiple sclerosis

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