Mortality in ankylosing spondylitis

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Increased mortality in ankylosing spondylitis

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Increased mortality in ankylosing spondylitis is related to disease severity,

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Factors negatively affecting outcomes :

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Male sex
Plus three of the following in the first two years of disease:

1. Erythrocyte sedimentation rate (ESR) >30 mm/h
2. Unresponsive to NSAIDs
3. Limitation of lumbar spine range of motion
4. Sausage-like fingers or toes
5. Oligoarthritis
6. Onset <16 years old

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Most frequent cause of death

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Circulatory disease is the most frequent cause of death.

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Cerebrovascular mortality

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People with AS have an increased risk of 60% for cerebrovascular mortality

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Vascular mortality

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Overall increased risk of 50% for vascular mortality

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Ankylosing spondylitis – articular and extra-articular complications

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1. Chronic pain and disability
2. Aortic regurgitation
3. Pulmonary fibrosis
4. Cauda equina syndrome
5. Mood disorders

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