Cervical Intraepithelial Neoplasia


High grade squamous intraepithelial lesion (HSIL) includes all except


A. Basal one-third only
B. Whole thickness
C. Whole thickness except one or two superficial layers
D. Basal half to two-third



LSIL, low grade squamous intraepithelial lesions includes


A. Severe dysplasia
B. Koilocytic atypia
C. Carcinoma in situ
D. Dyskaryotic cells



Carcinogenesis in cervix starts at the ‘transformation zone’ (TZ) by


A. Squamous metaplasia of the sub columnar reserve cells
B. Reduction in number of lactobacilli
C. Squamous epidermidization
D. Host cell immortalization



Risk factors in the genesis of cervical cancer are all except


A. Infection with high-risk HPV
B. Multiple types of HPV
C. Persistence of infection
D. Post menopause



HPV of high oncogenic risk is


A. 6
B. 11
C. 33
D. 42



True of HPV DNA is


A. Over 57 percent of patients with CIN and invasive cancer are found to be positive with HPV DNA.
B. HPV DNA detection in cervical tissues may be a screening procedure as that of Pap smear.
C. HPV infected cells (koilocytes) contain dispersed chromatin in the cytoplasm
D. Expression of p55 oncoproteins in the infected cells



Not true about koilocytes


A. Large cells
B. Columnar cell
C. Vacuolated cells
D. Contain perinuclear halo



In shorts


  • HPV Triage Strategy includes: Pap Smear test, HPV testing, Colposcopy
  • Exfoliative cytology, the gold standard for screening, should contain cells from SCJ, TZ and the endocervix.
  • Hybrid capture methods can reliably detect the high risk HPV types early.
  • Colposcopy is complementary and not a substitute for cytology.
  • Schiller’s test: Employing iodine solution (Schiller’s 0.3% or Lugol’s 5%), multiple punch biopsies can be taken from the unstained areas in absence of colposcopy.

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