Parathyroid hormone-related protein cause hypercalcemia by all of the following mechanism EXCEPT -
Parathyroid hormone-related protein
similarity in structure, it acts at the same receptor as PTH and causes bone resorption, increased phosphate excretion from the proximal tubules, and calcium reabsorption from the distal tubules. It does not have any effect on 1,25-dihydroxy vitamin D production.
Hungry bone syndrome seen after -
While mild hypocalcemia is common after partial parathyroidectomy, some people experience persistently prolonged low calcium levels. This is called hungry bone syndrome.
Denosumab mimics the natural action of -
Denosumab mimics the natural action of osteoprotegerin
Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor (OCIF) or tumour necrosis factor receptor superfamily
What s the mechanism of action of Denosumab?
Denosumab inhibits this maturation of osteoclasts by binding to and inhibiting RANKL.
Human monoclonal antibody useful for treatment of hypercalcemia?
Denosumab - Human monoclonal antibody against RANKL
Inhibits the maturation, function and survival of osteoclasts.
Most common cancer associated with hypercalcemia of malignancy is -
The most common cancer associated with hypercalcemia of malignancy is multiple myeloma which has the highest prevalence of hypercalcemia of malignancy.
Which of the following is the commonest pathophysiology of hypercalcemia of malignancy?
Excessive secretion of parathyroid hormone-related protein (PTHrP)
Excessive secretion of PTHrP is the most common cause of hypercalcemia of malignancy. It is also known as humoral hypercalcemia of malignancy (HHM) and accounts for about 80% of the cases.
Hypercalcemia of malignancy occurs in approximately ........ of all cancer patients during their clinical course.
Hypercalcemia of malignancy occurs in approximately 20% of all cancer patients during their clinical course.
All of the following causes Hypercalcemia EXCEPT -
Hypercalcemia - sarcoidosis, tuberculosis, Paget disease
Hypocalcemia is common in advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD)
Most common cause of hypercalcemia is -