Lung cancer

Lung cancer

Which of the following tumor develops hollow cavity and associated cell death at the center of the tumor?

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Squamous-cell carcinoma


Squamous-cell carcinoma causes about 30% of lung cancers. Occur close to large airways. Hollow cavity commonly found at the center of the tumor.

CK7 is present in many lung cancers, but absent from

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squamous cell carcinomas.


Adenocarcinomas tend to express Napsin-A and TTF-1; squamous cell carcinomas lack Napsin-A and TTF-1, but express p63 and its cancer-specific isoform p40

Which Adenocarcinoma of lung is most aggressive?

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lepidic subtype is associated with good prognosis, acinar and papillary subtypes show intermediate prognosis, whereas micropapillary and solid subtypes correlate with the worst prognosis

Leading cause of cancer death

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carcinoma lung


lung cancer is the most diagnosed type of cancer, and the leading cause of cancer death

"Driver mutations" – are particularly common in adenocarcinomas

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Adenocarcinoma

Small cell lung cancer are most commonly found near

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center of the lung


SCLC tumors are often found near the center of the lungs, in the major airways

Most common with carcinoma lung

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Hypercalcemia


Most common is hypercalcemia caused by over-production of parathyroid hormone-related protein or parathyroid hormone.

Horner's syndrome is common in lung tumors at

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Apex


Horner's syndrome - seen in Pancoast tumor which is a tumor of the apex of the lung.

Most common symptom of carcinoma lungs

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Cough

Which Adenocarcinoma of lung is least aggressive?

Correct! Wrong!

lepidic type adenocarcinoma - grow along the alveolar walls


lepidic subtype is associated with good prognosis, acinar and papillary subtypes show intermediate prognosis, whereas micropapillary and solid subtypes correlate with the worst prognosis

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