Hematology MCQs

Hematology MCQs

Medicine Question Bank

Criteria for AMML is confirmed if the myleoblasts and promonocytes in the bone marrow are greater than ?

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Criteria for AMML is confirmed if the myleoblasts and promonocytes in the bone marrow are greater than 20 percent.

All of the following are TRUE about AML EXCEPT -

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AML is slightly more common in men, with a male-to-female ratio of 1.3:1
Acute promyelocytic leukemia has the highest curability

Auer rods are seen in -

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Auer rods [also called Auer bodies] - are large, crystalline cytoplasmic inclusion bodies observed in myeloid blast cells -
- acute myeloid leukemia,
- acute promyelocytic leukemia,
- high-grade myelodysplastic syndromes
- myeloproliferative disorders.

Which cytogenetic abnormalities in pediatric and adult B-ALL shows favorable prognosis?

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Hyperdiploidy (>50 chromosomes) in B-ALL Shows Favorable prognosis

Which is the commonest malignancy in pediatrics age group?

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Most common types of cancer are leukemias, followed by brain and other CNS tumors, lymphomas, neuroblastoma, kidney tumors
Leukemias, which are cancers of the bone marrow and blood, are the most common childhood cancers. They account for about 28% of all cancers in children. The most common types in children are acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML)

Which is TRUE for Philadelphia chromosome EXCEPT ?

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All cases of CML are positive for BCR-ABL1
Fusion gene BCR-ABL1 - coding for a hybrid protein: a tyrosine kinase signalling protein that is "always on", causing the cell to divide uncontrollably by interrupting the stability of the genome and impairing various signaling pathways governing the cell cycle.

Blast crisis in CML is diagnosed if -

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Blast crisis in CML is diagnosed if -
>20% blasts in the blood or bone marrow
The presence of an extramedullary proliferation of blasts

What is the test of choice in adults to distinguish CML from Leukemoid reaction?

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Philadelphia chromosome is translocation between chromosomes -

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Philadelphia chromosome -Ph1 (a reciprocal translocation of chromosomal material between chromosomes 9 and 22)
BCR/ABL mutation

Hepatitis C virus (HCV) is considered as a riskfactor of -

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Both the hepatitis B virus (HBV) and hepatitis C virus (HCV) have been implicated in the pathogenesis of chronic lymphocytic leukemia

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