Sebaceous glands

All of the following are sebaceous glands except

A. Glands of Moll
B. Fordyce spots
C. Montgomery tubercles
D. Tyson glands

All are true regarding sebaceous glands except

A. Provides 90% of skin surface lipids
B. The product of this gland is synthesized via paracrine secretion
C. Unique to the sebaceous gland is the production of squalene
D. Meibomian glands open directly onto the skin

In addition to cell debris and lipids, sebum also contains all except

A. Antimicrobial substances
B. Corticotropin-releasing hormone
C. Matrix metalloproteinases
D. Type-1 isoform of 5-alpha-reductase

Not a function of sebaceous glands

A. Can regulate the activity of xenobiotics
B. Transports antioxidants in and on the skin
C. Sole responsible for development of acne
D. Has pro-inflammatory function

All are true of sebaceous glands and acne formation except

A. Conversion of testosterone to 5α-DHT can occur in sebocytes causing enhanced sebaceous gland activity
B. Corticotropin-releasing hormone (CRH) significantly induces sebaceous lipids production and is responsible for stress-induced exacerbation of acne
C. Facial skin from acne patients is characterized by rich innervation of substance P-containing nerves
D. Sebum FFA are involved in modulating the activity of Propionibacterium acnes in the human skin

In short

Testosterone and 5α-dihydrotestosterone (5α-DHT)

Acne patients produced higher rates of testosterone and 5α-dihydrotestosterone (5α-DHT) in their skin than healthy individuals.


Sebaceous function can be also significantly modified by histamine and conversely, antihistamines significantly decreases squalene levels in human sebaceous gland cells.

Western diet

Western diet, comprised of milk and hyperglycaemic foods, may have potentiating effects on serum insulin and insulin-like growth factor-I (IGF-I) levels, thereby promoting the development of acne

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