Glomerular Basement Membrane

Which is known as anti-glomerular basement membrane disease

A. Alport syndrome

B. Goodpasture’s syndrome

C. Fabry disease

D. Atypical hemolytic uremic syndrome

In Goodpasture’s syndrome damage to the basement membrane caused by antibodies to ————— of type IV collagen

A. alpha 4

B. alpha 3 NC1 domain

C. 7s

D. C4 domain at the C-terminus

Which of the following is a dumbbell-shaped Protein

A. Laminin

B. Collagen IV

C. Nidogen

D. Agrin

Which is the major heparan sulfate proteoglycan of the Glomerular Basement Membrane?

A. Syndecan

B. Glypican

C. Betaglycan 

D. Agrin

Which amino acid is required at every third position in collagen?

A. Lysine

B. Glycine

C. Leucine

D. Histidine

Dandy-Walker malformation and occipital cephalocele is a autosomal dominant condition, known as ADDWOC, caused by mutations in





Major components of the GBM include type IV collagen, laminin, and heparan sulfate proteoglycans, as in basement membranes at other sites

Major proteoglycans of the GBM are heparan sulfate proteoglycans, including perlecan and agrin.

GBM serves as the skeleton of the glomerular tuft.

GBM is a complexly folded sack with an opening at the glomerular hilum.

The outer aspect of GBM sack is completely covered with podocytes.

The interior of the sack is filled with the capillaries and the mesangium.

As a result, on its inner aspect, the GBM is in contact with either capillaries or the mesangium.

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