Physiology Review MCQs -II

Serum has a higher concentration of -

Correct! Wrong!

Serum has a higher serotonin (5 hydroxytryptamine -SHT) content because of the breakdown of platelets during clotting

Total blood volume is ----- % of body weight

Correct! Wrong!

Total blood volume is 8 % of body weight

Prealbumin is a transport protein for -

Correct! Wrong!

Prealbumin is a transport protein for thyroid hormones

Thyroid hormone-binding proteins with highest binding affinities -

Correct! Wrong!

Thyroxine - Binding globulin - highest binding affinity
Albumin - Poorest binding affinity

Which of the following is used as the immunohistochemical marker for choroid plexus papillomas

Correct! Wrong!

Transthyretin
Diagnostically, transthyretin (TTR), KIR7.1, cytokeratin and Ki67 immunohistochemistry are most helpful

Which medicine is FDA approved for treatment of transthyretin amyloid cardiomyopathy?

Correct! Wrong!

Tafamidis has been FDA approved for treatment of transthyretin amyloid cardiomyopathy.


Patisiran and Inotersen have been approved by the FDA for treatment of polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (hATTR) in adults.

Which NSAID have been shown to be inhibitors of transthyretin-related hereditary amyloidosis.

Correct! Wrong!

Diflunisal and several of its analogues have been shown to be inhibitors of transthyretin-related hereditary amyloidosis

Transthyretin is produced by all of the following EXCEPT-

Correct! Wrong!

Transthyretin is a protein that functions as a transporter of thyroxine and retinol and is produced chiefly by the liver (> 95%), with additional production within the choroid plexus of the brain and the retinal pigment epithelium.

Which of the following is mainly β-globulin?

Correct! Wrong!

Transferrin: α2- β globulin (mainly β -globulin),


Lipoprotein - α2-globulin plus lipid
Ceruloplasmin: α2- β globulin (mainly α2-globulin)
Haptoglobins: α2-globulin

In which order the proteins are regenerated after hemorrhage?

Correct! Wrong!

After haemorrhage - fibrinogen, globulin and albumin are regenerated in the same order

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