Salt-and-pepper chromatin
Contents
Which of the following commonly shows ‘salt-and-pepper chromatin’ on microscopy –
A. Compound palmar ganglion
B. Subserosal fibroid
C. Medullary thyroid carcinoma
D. Ovarian endometriomas
In-Shorts
What is ‘Salt-and-pepper chromatin’?
Also known as –
- Salt-and-pepper nuclei
- Stippled chromatin
Appearance – cell nuclei demonstrate granular chromatin on microscopy
Salt-and-pepper chromatin is typically seen in which conditions?
Endocrine tumours – medullary thyroid carcinoma, neuroendocrine tumours and pheochromocytoma
What is the diagnosis of Image?
A 41 year male complained of headaches, tachycardia and diaphoresis. He particularly complained excessive sweating at night. Now you are given with the following slide. CT Scan shows a mass in abdomen and biopsy advised.
Slide given below – high magnification, Hematoxylin and eosin stain.
What is your diagnosis with clinical correlation?
What is a typical finding noted here?
Histopathology of pheochromocytoma with typical features.
