Renin


Angiotensinogen is cleaved to form angiotensin I by


A. Renin

B. Angiotensin Converting Enzyme

C. Hydrolase

D. Aminotransferases



Renin is secreted in response to all of the following EXCEPT –

A. Decrease in arterial blood pressure

B. Decrease in blood volume

C. Increase in sodium load delivered to the distal tubule

D. Stimulation of β1 adrenergic receptors.



Renin cleave angiotensinogen to form angiotensin I by using which of the following activity?


A. Endopeptidase

B. Carboxypeptidase

C. Aminopeptidase

D. Prolinase


What is the primary function of Renin ?


A. Increase water retention

B. Increase in blood pressure

C. Stimulate Distal convoluted tubles

D. Reduce the blood pressure



What is the action of Candesartan?


A. ACE inhibitor

B. Renin inhibitor

C. Angiotensin II receptor blocker

D. Aminopeptidase



Aliskiren is classified as –


A. ACE inhibitor

B. Renin inhibitor

C. Angiotensin II receptor blocker

D. Aminopeptidase



Which of the following is correct?


A. Not effective in lowering blood pressure

B. Aliskiren is used with ARBs or ACE inhibitors in patients with GFR < 60 mL/min

C. Angiotensin II receptor antagonist

D. Pepstatin – the first renin inhibitor




In shorts


  • Renin secretion is also stimulated by sympathetic nervous stimulation, mainly through β1 adrenoreceptor activation

  • Aliskiren should not be used with ARBs or ACE inhibitors in patients with moderate to severe renal impairment – where glomerular filtration rate [GFR] < 60 mL/min

  • Pepstatin – the first renin inhibitor

Renin Inhibitor – Mechanism of Action


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