Oncology MCQs -4


Warburg Effect is seen in


A. Macrophages

B. Langhans’ giant cells

C. Xanthelasmatic giant cells

D. Cencer cells



Warburg effect is the observation that most cancer cells produce energy predominantly through


A. Citric acid cycle

B. Oxidative phosphorylation

C. Aerobic glycolysis

D. Electron transport chain



Which test help in swift screening of specific stability defects in individual cancer patients and used to probe point mutation?


A. PTEN Genetic Test

B. TP53 Genetic Test

C. Fast parallel proteolysis

D. BRCA Genetic Test



Representative Oncogenes for Chronic myelogenous leukemia


A. BCL2

B. BCR-ABL

C. PAX3-FOXO1

D. IL21R/BCL6



Sickle-cell anemia is caused by a point mutation in the


A. α-globin chain of hemoglobin

B. β-globin chain of hemoglobin

C. γ-globin chain of hemoglobin

D. δ-globin chain of hemoglobin



Sickle-cell anemia is caused by


A. Deletion

B. Point mutation

C. Translation

D. Translocation



Sickle-cell anemia is caused by substitution


A. Lysine-for-glutamic acid

B. Valine-for-glutamic acid

C. Lysine-for-Histidine

D. Valine-for-Histidine



Sickle-cell anemia is caused by substitution

A. Lysine-for-glutamic acid at 6th position

B. Valine-for-glutamic acid at 9th position

C. Valine-for-glutamic acid at 6th position

D. Lysine-for-glutamic acid at 9th position



β-globin gene is found on the short arm of


A. Short arm of chromosome 11

B. Short arm of chromosome 19

C. Long arm of chromosome 11

D. Long arm of chromosome 11



Sickle-cell anemia is an


A. Autosomal recessive

B. X-linked recessive

C. Autosomal dominant

D. X-linkedrecessive



In shorts


Neurofibromatosis is caused by point mutations in the Neurofibromin 1 or Neurofibromin 2 gene


Sickle-cell anemia is caused by a point mutation in the β-globin chain of hemoglobin, causing the hydrophilic amino acid glutamic acid to be replaced with the hydrophobic amino acid valine at the sixth position


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