Image Question-23

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What is the diagnosis of Image?

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Bhatt S, Simon R, Dogra VS., CC BY 3.0 https://creativecommons.org/licenses/by/3.0, via Wikimedia Commons

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What is the diagnosis of histopathological slide?

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A. Fessas  body

B. Gamna-Gandy body

C. Lafora body

D. Mallory body

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Gamna-Gandy bodies

	Gamna-Gandy bodies
Other names	Tobacco flecks or Siderotic nodules
Appearance	Yellow-brownish and spheroidal foci within the splenic parenchyma
Composition	Deposits of iron pigments and calcium salts
Associated with	Granulomatous inflammatory reactions with multinucleated foreign-body giant cells
Common Conditions	Portal hypertension , Sickle cell disease

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What are Fessas bodies?

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Fessas bodies – intracellular inclusion bodies in peripheral blood smears of patients with thalassemias.

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Neoplastic Diseases may have Gamna-Gandy bodies

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• Thymoma
• Thyroid Follicular Adenoma
• Pituitary Adenoma
• CNS Neoplasms
• Hairy Cell Leukemia
• Hodgkin and non-Hodgkin Lymphoma
• Cardiac Myxomas
• Angiosarcoma
• Ovary Carcinoma
• Liver Carcinoma
• Renal Cell Carcinoma
• Breast Cancer
• Gastric Neurinoma

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Non-neoplastic Diseases

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• Portal Hypertension
  
• Thrombotic Thrombocytopenic Purpura
  Idiopathic Thrombocytopenic Purpura
• Hemolytic Anemia
• Paroxysmal Nocturnal Hemoglobinuria
• Acquired Hemochromatosis
• Congestive Splenomegaly
• Retroperitoneal Lymph Nodes

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Splenic Gandy-Gamna body

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