Ovarian Failure


The most common genetic form of premature ovarian insufficiency ( POI) is


A. Fragile X syndrome
B. Turner syndrome
C. Autoimmune thyroiditis
D. Addison’s disease



Anti-ovarian antibodies in Autoimmune thyroiditis are against


A. All steroid producing cells in ovary
B. Granulosa cells only
C. Theca cells
D. Steroid producing cells and gonadotropin receptors



Autoimmune polyglandular syndromes (APS) is best characterized by


A. Accumulation of dendritic cells and lymphocytes causing tissue damage
B. APS 2 is a syndrome characterized by chronic muco-cutaneous candidiasis, hypoparathyroidism, and primary adrenal insufficiency,
C. APS 1 is characterized by type 1 diabetes mellitus (T1DM), Addison Disease, and Hypothyroidism
D. APS-3 have an increased mortality risk, due to adrenal crises



Accelerated ovarian aging is seen in all except


A. Endometriosis
B. Smoking
C. Use of gonadotropin releasing hormone agonists (GnRHa)
D. Tuberculosis



Most frequent autoimmune disorder associated with premature ovarian failure is


A. Hashimoto’s disease
B. Additions disease
C. Type 1 Diabetes Mellitus
D. Polycystic ovary syndrome (PCOS)



In Shorts


The use of mesenchymal stem cells (MSCs) has been emerging as a treatment option for patients with POI. Stem cell therapy has particularly been studied in the setting of iatrogenic ovarian destruction and shown great promise.

Ovulatory disorders are the leading cause of infertility classified into three categories according to the World Health Organization.

Group III ovulatory disorders involve multiple complex etiologies causing premature ovarian insufficiency (or failure), including genetic, iatrogenic and acquired causes.


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