Coffee Bean Nuclei
Seen in –
- Granulosa cell tumors.
- Brenner tumor
Granulosa cell tumors
Tumors consists of – monotonous islands of granulosa cells with “coffee-bean” nuclei.
- Usually arises from squamous metaplasia of surface epithelium.
- Gross picture of Brenner is similar to that of fibroma.
- Histologically islands of transitional epithelium – Walthard nests.
- Compact fibrous stroma
- Cells look like “coffee bean” as the nuclei have longitudinal grooves.
Benign or Malignant
Majority are Benign, but some can be Malignant
- Benign Brenner tumor:
- Small usually < 2 cm
- fibrous tumor
- uniform cut surface
- Calcifications may be present
- Borderline and malignant Brenner tumor:
- Smooth surface,
- larger (usually > 10 cm)
- polypoid masses projecting into cystic cavity(s)