Downey cells

Seen in EBV infection

Downey type I cells

Downey type I cells are slightly larger than normal lymphocytes (figure, A, inset), with indented or so-called bean-shaped nuclei. They also have reduced cytoplasm—often containing a few azurophilic granules and vacuoles.

Downey type II cells

Downey type II cells are the most frequently observed Downey cells; they are larger with abundant pale cytoplasm and often abut or partly surround adjacent red blood cells

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