Image Question-37

What is the diagnosis of the cell shown in Image?

A. M-Cell

B. Cart Wheel cell

C. Flame cell

D. Mott Cell

Wright-Giemsa stain

Flame cells are atypical plasma cells with irregular cytoplasmic projections that stain bright purple-red with Wright-Giemsa stain.

IgA myeloma

They are usually associated with IgA myeloma

Other conditions

May be seen in other conditions-

  1. Non-IgA myelomas
  2. MGUS
  3. Reactive plasmacytosis

What is the cause of characteristic staining of ‘flame cell’?

The characteristic staining – related to the high carbohydrate content of IgA molecules.

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