Image Question-38

What is the diagnosis of the cell shown in figure?

A. Hensen’s cells

B. Oxyphil cell

C. Mott cell

D. Club cell

Mott Cell

Mott cells

Mott cells are plasma cells that have spherical inclusions packed in their cytoplasm.

Highly refractile inclusion bodies -variable size

Russell bodies

These inclusion bodies are – Spherical inclusions

Russell bodies

Present within a single plasma cell having an eccentrically placed clock face nucleus

What is the structure of Russel bodies?

These inclusions are Russell bodies which are dilated endoplasmic reticulum cisternae containing condensed immunoglobulins (Ig)

Ultrastructural studies- inclusions are made up of condensed Ig’s within vesicular structures derived from dilated endoplasmic reticulum cisternae.

“Bunch of grapes” appearance of the plasma cell cytoplasm

Mott cells have the classic “bunch of grapes” appearance of the plasma cell cytoplasm packed with Ig inclusions (Russell bodies).

Mott cells can be seen in

  1. Plasma cell dyscrasias
  2. Reactive plasmacytoses
  3. Chronic inflammatory conditions
  4. Autoimmune-mediated diseases (eg, Hashimoto’s thyroiditis and rheumatoid arthritis),
  5. Wiskott-Aldrich syndrome
  6. von Recklinghausen’s neurofibromatosis.

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