Congenital/ infectious disorders of Skin


All are true of chromosome 9 except


A. Translocation of genetic material between chromosomes 9 and 22 causes chronic myeloid leukemia
B. Deletions of part or all of chromosome 9 are commonly found in bladder cancer
C. 9q 22.3 microdeletion is found in Gardner’s syndrome
D. Xeroderma pigmentosum is caused by an abnormality on the ‘patched’ gene of Ch. 9q



Not true regarding neurofibromatosis is


A. 30% are autosomal dominant and 70% arise from sporadic mutations
B. NF 1 arises from a gene mutation on chromosome (Ch.) 17.
C. Lisch nodules are seen early in life
D. Vestibular schwannomas (VS) are found in NF 2 variant



Which one of the following is a primary disorder of skin


A. Necrobiosis lipoidica

B. Pyoderma gangrenosum

C. Granuloma annulare

D. Hidradenitis Suppurativa



Honey-coloured crust is characteristic of 


A. Impetigo

B. Erysipelas

C. Necrotising fasciitis

D. ymphangitis



The commonest causative organism of cellulitis is


  A.  Streptococcus

  B.  Staphylococcus

  C.  Bacteroides

  D.  Pseudomonas



In short


  • Meleney’s synergistic gangrene and Fournier’s gangrene are variants of Necrotising fasciitis. Most commonly a streptococcal species (Group A β-haemolytic) in combination with Staphylococcus, Escherichia coli, Pseudomonas, Proteus, Bacteroides or Clostridia involved as a causative agent. Lymphangitis is absent in such lesions.
  • Purpura fulminans is most common in children under 7 years, following an upper respiratory tract infection, or in asplenia. It is secondary to either an acute bacterial (Neisseria meningitidis) or viral infection (varicella).
  • Ferguson-Smith syndrome is a rare, autosomal-dominantly inherited abnormality on Ch. 9q in which affected individuals develop multiple self-healing squamous cell carcinomas (SCC).

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