Dermatomyositis Autoantibodies
Contents
- 1 Anti-Jo:
- 2 Anti-Mi2 (directed against-helicase):
- 3 Anti- SRP (directed against signal recognition particle):
- 4 Anti- MDA5 (melanoma differentiation-associated gene 5):
- 5 Anti- TIF-1 gamma (transcription intermediary factor) /Anti-p155/140:
- 6 Anti-SAE (ubiquitin-like modifier activating enzyme):
- 7 Anti-NXP2 (nuclear matrix protein 2):
Autoantibodies are associated with specific complications and findings:
Anti-Jo:
Antisynthetase syndrome consisting of interstitial lung disease, mechanic’s hands, Raynaud phenomenon, sclerodactyly, and arthritis.
Anti-Mi2 (directed against-helicase):
Acute onset disease, V-neck sign, and shawl rash
Anti- SRP (directed against signal recognition particle):
Severe myositis, resistant to treatment
Anti- MDA5 (melanoma differentiation-associated gene 5):
Severe cutaneous involvement, amyopathic dermatomyositis, and rapidly progressive ILD
Anti- TIF-1 gamma (transcription intermediary factor) /Anti-p155/140:
Malignancy
Anti-SAE (ubiquitin-like modifier activating enzyme):
Dysphagia, skin disease preceding myositis
Anti-NXP2 (nuclear matrix protein 2):
Calcinosis cutis
