Salt-and-pepper chromatin

Which of the following commonly shows ‘salt-and-pepper chromatin’ on microscopy –

A. Compound palmar ganglion

B. Subserosal fibroid

C. Medullary thyroid carcinoma

D. Ovarian endometriomas


What is ‘Salt-and-pepper chromatin’?

Also known as –

  • Salt-and-pepper nuclei
  • Stippled chromatin

Appearance – cell nuclei demonstrate granular chromatin on microscopy

Salt-and-pepper chromatin is typically seen in which conditions?

Endocrine tumours – medullary thyroid carcinoma, neuroendocrine tumours and pheochromocytoma

What is the diagnosis of Image?

A 41 year male complained of headaches, tachycardia and diaphoresis. He particularly complained excessive sweating at night. Now you are given with the following slide. CT Scan shows a mass in abdomen and biopsy advised.

Slide given below – high magnification, Hematoxylin and eosin stain.

What is your diagnosis with clinical correlation?

What is a typical finding noted here?

Pheochromocytoma high mag

Histopathology of pheochromocytoma with typical features.

Histopathology of pheochromocytoma
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