Neurology Notes : Wilbrand’s knee

Wilbrand’s knee:

Inferonasal fibres of the optic nerve which go into the contralateral optic nerve 4 mm before crossing over to the opposite optic tract.

A lesion here produces a junctional scotoma in the superior temporal field of the optic nerve opposite the site of injury.

Most commonly associated tumor associated with – Rapidly progressive bilateral visual loss caused by paraneoplastic processes

Small cell carcinoma of lung

Most common inherited optic neuropathy is

Dominant optic atrophy – autosomal dominant

Most common causes of unilateral optic disc edema –

  • Nonarteritic anterior ischemic optic neuropathy (NAION)
  • Optic neuritis
  • Orbital compressive lesions

Most common carcinoma metastasize to the optic nerve

Carcinoma Breast and Lung carcinomas

Antibody most commonly identified and directed toward –

  • Paraneoplastic optic neuropathy,- antibodies to collapsin response mediator protein 5 (CRMP5).
  • Paraneoplastic retinopathies-cancer-associated retinopathy – antibodies to recoverin protein
  • Melanoma-associated retinopathy – antibodies to rod ganglion cells

Which infectious disorder most commonly associated with significant papilledema?

Cryptococcal meningitis

Which Vitamin is associated with risk of Pseudotumor cerebri?

Vitamin A

Optic Disc Drusen

Optic disc drusen- common cause of pseudopapilledema,

Due to calcium deposits within the optic nerve head.

Most common causes of unilateral retrobulbar optic neuropathy –

Optic neuritis and compressive lesions.

Lhermitte sign

Electric shock-like sensations radiating down the spine, which may be transmitted into the extremities. Occur with neck flexion

This phenomenon may occur with lesions of the posterior columns, most commonly from MS

Most common cause of inherited chorea –

Huntington disease

Asterixis – Liver Flap is Example of ————— myoclonus.

Negative myoclonus

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