Neurology Notes : Wilbrand’s knee


Wilbrand’s knee:


Inferonasal fibres of the optic nerve which go into the contralateral optic nerve 4 mm before crossing over to the opposite optic tract.

A lesion here produces a junctional scotoma in the superior temporal field of the optic nerve opposite the site of injury.


Most commonly associated tumor associated with – Rapidly progressive bilateral visual loss caused by paraneoplastic processes


Small cell carcinoma of lung


Most common inherited optic neuropathy is


Dominant optic atrophy – autosomal dominant


Most common causes of unilateral optic disc edema –


  • Nonarteritic anterior ischemic optic neuropathy (NAION)
  • Optic neuritis
  • Orbital compressive lesions

Most common carcinoma metastasize to the optic nerve


Carcinoma Breast and Lung carcinomas


Antibody most commonly identified and directed toward –

  • Paraneoplastic optic neuropathy,- antibodies to collapsin response mediator protein 5 (CRMP5).
  • Paraneoplastic retinopathies-cancer-associated retinopathy – antibodies to recoverin protein
  • Melanoma-associated retinopathy – antibodies to rod ganglion cells

Which infectious disorder most commonly associated with significant papilledema?


Cryptococcal meningitis


Which Vitamin is associated with risk of Pseudotumor cerebri?


Vitamin A


Optic Disc Drusen


Optic disc drusen- common cause of pseudopapilledema,

Due to calcium deposits within the optic nerve head.


Most common causes of unilateral retrobulbar optic neuropathy –


Optic neuritis and compressive lesions.


Lhermitte sign


Electric shock-like sensations radiating down the spine, which may be transmitted into the extremities. Occur with neck flexion

This phenomenon may occur with lesions of the posterior columns, most commonly from MS


Most common cause of inherited chorea –


Huntington disease


Asterixis – Liver Flap is Example of ————— myoclonus.

Negative myoclonus


SubscribeMedicine MCQs with Answers

For Medical Students & Doctors. Share with Your Friends & Encourage Us.

Enable Notifications OK No thanks