Na, K-ATPase conformational change E1 to E2


Na, K-ATPase conformational change where E1 becomes E2 is associated with phosphorylation of ——– residue of E1


[A] Valine
[B] L-glutamate
[C] Aspartate
[D] Pyruvate



Na, K-ATPase – E1 and E2


  1. Forms of Sodium Pump – Na+-K+ ATPase exists in two forms: E1 and E2.
  2. Phosphorylation of aspartate residue of E1 with the help of ATP and Mg++ results in conformational change and E1 becomes E2
  3. Dephosphorylation changes the conformation of E2 to E1

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