Medicine MCQs

Medicine MCQs -6 : Folates

Large amounts of supplemental folic acid can hide ------------- deficiency

Correct! Wrong!

Large amounts of supplemental folic acid can hide vitamin B12 deficiency

Folate is also known as -

Correct! Wrong!

Folate- vitamin B9

Vitamin B1
Required as coenzyme in the catabolism of sugars and amino acids.
Vitamin B2
A precursor of coenzymes called FAD and FMN, which are required for flavoprotein enzyme reactions. Vitamin B3
Niacin (nicotinic acid)
A precursor of coenzymes called NAD and NADP required for metabolic processes.
Nicotinamide riboside
Vitamin B5
Pantothenic acid
A precursor of coenzyme A
metabolize many molecules.
Vitamin B6
Required as coenzyme in metabolism.
Vitamin B7
Coenzyme for carboxylase enzymes
Required for of fatty acids and in gluconeogenesis.
Vitamin B9
Required for repair, and methylate DNA;
Cofactor in various reactions involving rapid cell division and growth, such as in infancy and pregnancy.
Vitamin B12
Coenzyme involved DNA synthesis and regulation,fatty acid metabolism and amino acid metabolism.

Elevated Methyl malonic acid levels indicate ---------- deficiency

Please select 2 correct answers

Correct! Wrong!

vitamin B12

Which of the following mediates uptake of methotrexate by cells?

Correct! Wrong!

Reduced folate transporter -mediates uptake of methotrexate by cells.

Which vitamin deficiency causes 'methylfolate trap' ?

Correct! Wrong!

Vitamin -B12 -
THF starvation or the methylfolate trap:
MTHF accumulates in plasma
Intracellular folate concentrations fall due to failure of formation of THF

Which is the most frequently affected tissues in folate and vitamin - B12 deficiency?

Correct! Wrong!

Marrow - most commonly affected tissue in folate and vitamin - B12 deficiency

Next most frequently affected tissues are -
Small intestine
Female genital tracts.

Risk of neural tube defects is associated with deficiency of -

Correct! Wrong!

Folic acid is- supplement by women during pregnancy to reduce the risk of neural tube defects

All of the following enzyme deficiency cause homocystinuria EXCEPT ?

Correct! Wrong!

Deficiency of enzymes that cause homocystinuria -

- Methionine synthase
- Cystathionine synthase

Folates are best absorbed from -

Correct! Wrong!

Folates are best absorbed from the upper small intestine

Deficiency of iron may be masked by which vitamin deficiency?

Correct! Wrong!

Deficiency of folic acid or vitamin B12 may mask the deficiency of iron

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Medicine MCQs – 6 : Folates

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