Medicine MCQs -6 : Folates
Which of the following mediates uptake of methotrexate by cells?
Reduced folate transporter -mediates uptake of methotrexate by cells.
Which is the most frequently affected tissues in folate and vitamin - B12 deficiency?
Marrow - most commonly affected tissue in folate and vitamin - B12 deficiency
Next most frequently affected tissues are -
Female genital tracts.
Folate is also known as -
Folate- vitamin B9 https://medicalwikipedia.org/
Required as coenzyme in the catabolism of sugars and amino acids.
A precursor of coenzymes called FAD and FMN, which are required for flavoprotein enzyme reactions. Vitamin B3
Niacin (nicotinic acid)
A precursor of coenzymes called NAD and NADP required for metabolic processes.
A precursor of coenzyme A
metabolize many molecules.
Required as coenzyme in metabolism.
Coenzyme for carboxylase enzymes
Required for of fatty acids and in gluconeogenesis.
Required for repair, and methylate DNA;
Cofactor in various reactions involving rapid cell division and growth, such as in infancy and pregnancy.
Coenzyme involved DNA synthesis and regulation,fatty acid metabolism and amino acid metabolism.
All of the following enzyme deficiency cause homocystinuria EXCEPT ?
Deficiency of enzymes that cause homocystinuria -
- Methionine synthase
- Cystathionine synthase
Which vitamin deficiency causes 'methylfolate trap' ?
Vitamin -B12 -
THF starvation or the methylfolate trap:
MTHF accumulates in plasma
Intracellular folate concentrations fall due to failure of formation of THF
Elevated Methyl malonic acid levels indicate ---------- deficiency
Please select 2 correct answers
Risk of neural tube defects is associated with deficiency of -
Folic acid is- supplement by women during pregnancy to reduce the risk of neural tube defects
Deficiency of iron may be masked by which vitamin deficiency?
Deficiency of folic acid or vitamin B12 may mask the deficiency of iron
Large amounts of supplemental folic acid can hide ------------- deficiency
Large amounts of supplemental folic acid can hide vitamin B12 deficiency
Folates are best absorbed from -
Folates are best absorbed from the upper small intestine
Medicine MCQs – 6 : Folates