Pretibial myxedema

Pretibial myxedema is a localized lesions of the skin resulting from the deposition of

  • [A] Fluid
  • [B] Hyaluronic acid
  • [C] beta-2 microglobulin
  • [D] Transthyretin

All of the following are TRUE for Pretibial myxedema EXCEPT

  • [A] almost always preceded by the ocular signs found in Graves’ disease
  • [B] peau d’orange (orange peel) appearance
  • [C] non-pitting edema of the skin
  • [D] biopsy of the affected skin commonly reveals increase in fibroblasts

Pretibial myxedema

  • Nearly always associated with autoimmune thyroid disease – Graves Disease
  • Most often confined to the pretibial area, it may occur anywhere on the skin, especially the ankle, dorsum of the foot, knees, shoulders, elbows, upper back, pinnae, nose, and neck

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