Pretibial myxedema

Contents

1 Pretibial myxedema is a localized lesions of the skin resulting from the deposition of
2 All of the following are TRUE for Pretibial myxedema EXCEPT
3 Pretibial myxedema

Pretibial myxedema is a localized lesions of the skin resulting from the deposition of

[A] Fluid
[B] Hyaluronic acid
[C] beta-2 microglobulin
[D] Transthyretin

ANSWER

[B] Hyaluronic acid

Pretibial myxedema – more appropriately, thyroid dermopathy, is a term used to describe localized lesions of the skin resulting from the deposition of hyaluronic acid, usually as a component of thyroid disease.

All of the following are TRUE for Pretibial myxedema EXCEPT

[A] almost always preceded by the ocular signs found in Graves’ disease
[B] peau d’orange (orange peel) appearance
[C] non-pitting edema of the skin
[D] biopsy of the affected skin commonly reveals increase in fibroblasts

ANSWER

[D] biopsy of the affected skin reveals increase in fibroblasts

Biopsy of the affected skin reveals mucin in the mid- to lower- dermis. There is no increase in fibroblasts. Over time, secondary hyperkeratosis may occur, which may become verruciform.

Nearly always associated with autoimmune thyroid disease – Graves Disease
Most often confined to the pretibial area, it may occur anywhere on the skin, especially the ankle, dorsum of the foot, knees, shoulders, elbows, upper back, pinnae, nose, and neck

M	T	W	T	F	S	S
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Pretibial myxedema is a localized lesions of the skin resulting from the deposition of

All of the following are TRUE for Pretibial myxedema EXCEPT

Pretibial myxedema

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