Nitric Oxide Synthas
Nitric oxide is synthesized by the oxidation of L-arginine
[A] Lysine
[B] L-ornithine
[C] L-arginine
[D] Cysteine
Which of the following is FALSE
[A] small amount of NO produced by nNOS and eNOS are noted in physiological state
[B] NO produced by eNOS plays a protective role in vascular endothelium and vascular function
[C] iNOS will produce a large amount of NO in normal state
[D] Neutrophils express iNOS
Nitric oxide is synthesized by the oxidation of L-arginine by nitric oxide synthase (NOS) expressed in cardiac myocytes.
NOS can be divided into three subtypes
- – Neuronal nitric oxide synthase (nNOS)
- – Inducible nitric oxide synthase (iNOS)
- – Endothelial nitric oxide synthase (eNOS)
- iNOS -Inducible nitric oxide synthase
iNOS are not responsible for producing NO in normal physiological state.
iNOS will produce a large amount of NO when an inflammatory response occurs
In humans, neutrophils also express iNOS.