Reticulocytes


Reticulocytes all are TRUE EXCEPT


A. Produced in the bone marrow

B. Immature red blood cells

C. Mature into RBCs in 7 days

D. Indicator of erythropoiesis activity



In comparison to a mature RBC reticulocytes have all of the following EXCEPT

A. Immature

B. Greater volume

C. Lower hemoglobin content

D. Lower hemoglobin concentration



Which is corrected reticulocyte count used in anemias?


A. Reticulocyte count

B. Reticulocyte production index

C. Immature reticulocyte fraction

D. Reticulocyte hemoglobin content



Reticulocyte hemoglobin content less than 28 pg is a good predictor for


A. Glucose-6-phosphate dehydrogenase (G6PD) deficiency

B. Hereditary spherocytosis

C. Sickle cell anemia

D. Iron deficiency anemia



In shorts


Flow cytometry is the most typical method of counting reticulocytes

Reticulocytes can only synthesize hemoglobin while in the bone marrow. Thus, once they enter the peripheral blood, they have the maximum hemoglobin content they can have

Increased reticulocyte percentages are seen in hemolytic disorders, whether intrinsic (e.g., hemoglobinopathy or enzymopathy) or extrinsic (e.g., traumatic, heart valve, acquired immune hemolytic anemia).

As long as the hemolytic cause is not corrected, the reticulocyte count will remain elevated. 


Reference ranges for the reticulocyte count
1Adult/elderly/child 0.5-2%
2Infant 0.5-3.1%
3Newborn2.5-6.5%
Reference ranges for the reticulocyte count

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