Primary Amenorrhea

The prevalence of primary amenorrhea is –

A. 2%
B. 4%
C. 0.1%
D. 0.9%

All of the following can cause primary amenorrhoea except

A. Empty Sella Syndrome
B. Swyer syndrome
C. P450 oxidoreductase deficiency
D. Meigs syndrome

The most common cause of primary amenorrhea is –

A. Müllerian agenesis
B. Constitutional delay of puberty
C. Endocrine disorders
D. Gonadal dysgenesis

Primary amenorrhea with hirsutism suggests

B. Pituitary tumor
C. GnRH deficiency
D. 17,20-lyase deficiency

Most common congenital anomaly leading to primary amenorrhea among Korean population –

A. Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome
B. Turners syndrome
C. Kallmans syndrome
D. Swyer syndrome

Ovarian cryopreservation is suggested for –

A. Swyer syndrome
C. Turners syndrome
D. Androgen insensitivity

In shorts

  • Kallmann syndrome is an X-linked disorder, which is characterized by delayed puberty and anosmia. Kallmann syndrome results from mutations that cause a defect in migration of the GnRH neurons and the olfactory neurons
  • Anti-Müllerian hormone (AMH) is normally secreted in androgen insensitivity syndrome (AIS). 
  • 5-Alpha-reductase deficiency requires standard surgical repair operations such as chordee correction, orchidopexia, and urethral reconstruction between 6 and 18 months of age to be raised as a male. If the child is raised as a female, surgical correction of the external genitalia should be considered and gonadal tissue should be removed early to prevent masculinization before puberty

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