Pretibial myxedema

Pretibial myxedema is a localized lesions of the skin resulting from the deposition of

• [A] Fluid
• [B] Hyaluronic acid
• [C] beta-2 microglobulin
• [D] Transthyretin

All of the following are TRUE for Pretibial myxedema EXCEPT

• [A] almost always preceded by the ocular signs found in Graves’ disease
• [B] peau d’orange (orange peel) appearance
• [C] non-pitting edema of the skin
• [D] biopsy of the affected skin commonly reveals increase in fibroblasts

Pretibial myxedema

• Nearly always associated with autoimmune thyroid disease – Graves Disease
• Most often confined to the pretibial area, it may occur anywhere on the skin, especially the ankle, dorsum of the foot, knees, shoulders, elbows, upper back, pinnae, nose, and neck