Nitric Oxide Synthas

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Nitric oxide is synthesized by the oxidation of L-arginine

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[A] Lysine
[B] L-ornithine
[C] L-arginine
[D] Cysteine

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Which of the following is FALSE

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[A] small amount of NO produced by nNOS and eNOS are noted in physiological state
[B] NO produced by eNOS plays a protective role in vascular endothelium and vascular function
[C] iNOS will produce a large amount of NO in normal state
[D] Neutrophils express iNOS

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Nitric oxide is synthesized by the oxidation of L-arginine by nitric oxide synthase (NOS) expressed in cardiac myocytes.

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NOS can be divided into three subtypes

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• – Neuronal nitric oxide synthase (nNOS)
• – Inducible nitric oxide synthase (iNOS)
• – Endothelial nitric oxide synthase (eNOS)

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• iNOS -Inducible nitric oxide synthase

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iNOS are not responsible for producing NO in normal physiological state.

iNOS will produce a large amount of NO when an inflammatory response occurs

In humans, neutrophils also express iNOS.

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