Medicine MCQs -6 : Folates
Contents
- 1 Which of the following mediates uptake of methotrexate by cells?
- 2 Which vitamin deficiency causes 'methylfolate trap' ?
- 3 Which is the most frequently affected tissues in folate and vitamin - B12 deficiency?
- 4 Folate is also known as -
- 5 Large amounts of supplemental folic acid can hide ------------- deficiency
- 6 All of the following enzyme deficiency cause homocystinuria EXCEPT ?
- 7 Elevated Methyl malonic acid levels indicate ---------- deficiency
- 8 Folates are best absorbed from -
- 9 Deficiency of iron may be masked by which vitamin deficiency?
- 10 Risk of neural tube defects is associated with deficiency of -
Which of the following mediates uptake of methotrexate by cells?
Reduced folate transporter -mediates uptake of methotrexate by cells.
Which vitamin deficiency causes 'methylfolate trap' ?
Vitamin -B12 -
THF starvation or the methylfolate trap:
MTHF accumulates in plasma
Intracellular folate concentrations fall due to failure of formation of THF
Which is the most frequently affected tissues in folate and vitamin - B12 deficiency?
Marrow - most commonly affected tissue in folate and vitamin - B12 deficiency
Next most frequently affected tissues are -
Mouth,
Stomach,
Small intestine
Respiratory,
Urinary,
Female genital tracts.
Folate is also known as -
Folate- vitamin B9 https://medicalwikipedia.org/
Vitamin B1
Thiamine
Required as coenzyme in the catabolism of sugars and amino acids.
Vitamin B2
Riboflavin
A precursor of coenzymes called FAD and FMN, which are required for flavoprotein enzyme reactions. Vitamin B3
Niacin (nicotinic acid)
A precursor of coenzymes called NAD and NADP required for metabolic processes.
Nicotinamide
Nicotinamide riboside
Vitamin B5
Pantothenic acid
A precursor of coenzyme A
metabolize many molecules.
Vitamin B6
Pyridoxine
Required as coenzyme in metabolism.
Pyridoxal
Pyridoxamine
Vitamin B7
Biotin
Coenzyme for carboxylase enzymes
Required for of fatty acids and in gluconeogenesis.
Vitamin B9
Folate
Required for repair, and methylate DNA;
Cofactor in various reactions involving rapid cell division and growth, such as in infancy and pregnancy.
Vitamin B12
Cobalamins
Coenzyme involved DNA synthesis and regulation,fatty acid metabolism and amino acid metabolism.
Large amounts of supplemental folic acid can hide ------------- deficiency
Large amounts of supplemental folic acid can hide vitamin B12 deficiency
All of the following enzyme deficiency cause homocystinuria EXCEPT ?
Deficiency of enzymes that cause homocystinuria -
- Methionine synthase
- MTHFR
- Cystathionine synthase
Elevated Methyl malonic acid levels indicate ---------- deficiency
Please select 2 correct answers
vitamin B12
Folates are best absorbed from -
Folates are best absorbed from the upper small intestine
Deficiency of iron may be masked by which vitamin deficiency?
Deficiency of folic acid or vitamin B12 may mask the deficiency of iron
Risk of neural tube defects is associated with deficiency of -
Folic acid is- supplement by women during pregnancy to reduce the risk of neural tube defects
Medicine MCQs – 6 : Folates
