Inflammatory Bowel Disease
Contents
- 1 All are true of Inflammatory Bowel Disease except
- 2 Complications of Inflammatory Bowel Disease includes all except
- 3 The most common complication of Crohn’s disease is
- 4 All are true of Inflammatory Bowel Disease except
- 5 All are indications for surgery in Crohn’s disease except
- 6 In short
- 7 Anti-TNF-α antibodies
- 8 Infliximab
- 9 Medications
- 10 ‘string’ sign of Kantor
All are true of Inflammatory Bowel Disease except
A. Folate and vitamin D deficiency is more common in Crohn’s disease
B. More than 50% of people with Ulcerative Colitis suffer from iron deficiency
C. In Ulcerative Colitis, the large intestine becomes inflamed sparing small intestine
D. Crohn’s disease affects only the innermost part of the bowel wall
Complications of Inflammatory Bowel Disease includes all except
A. Biliary stones are commonly associated with Crohn’s disease
B. Osteoporosis is more common in Ulcerative colitis
C. Fistula and rectal lesions are complications of Crohn’s disease
D. Colon cancer is more common with Crohn’s disease
The most common complication of Crohn’s disease is
A. Nutritional deficiencies as a result of poor absorption
B. Blockage of the intestine due to swelling
C. Diarrhea and weight loss
D. Bleeding from the rectum
All are true of Inflammatory Bowel Disease except
A. TNF-α plays a major role in the inflammation
B. Granulomas are most specific for Crohn’s disease
C. Distortion of crypt architecture is a feature of Crohn’s disease
D. Continuous mucosal lesions are characteristics of ulcerative colitis
All are indications for surgery in Crohn’s disease except
A. Recurrent intestinal obstruction
B. Intestinal fistula
C. Localized disease
D. Perianal disease (abscess, fistula, stenosis)
In short
Anti-TNF-α antibodies
Anti-TNF-α antibodies are frequently used to treat IBD because they are able to efficiently reduce the amount of TNF-α in the body.
Infliximab
Recent studies suggest that infliximab, a monoclonal antibody, is a potential treatment for Crohn’s disease because it neutralizes TNF-α.
Infliximab cannot be administered orally, since the digestive system would destroy it, and needs to be administered via an intravenous infusion at 6–8-week intervals.
Medications
Medications used to treat the symptoms of IBD include anti-inflammatory drugs, such as 5-aminosalicylic acid, and immunomodulators, such as azathioprine, mercaptopurine, methotrexate, infliximab, adalimumab, certolizumab, and natalizumab.
Although thalidomide is beneficial in dampening the production of proinflammatory cytokines, it has several limitations, including drowsiness, hypertension, skin rash, edema, and neutropenia.
‘string’ sign of Kantor
The ‘string’ sign of Kantor: High-resolution ultrasound with Small bowel enema examination show narrow terminal ileum involved with Crohn’s disease
